PRENATAL STRESS DOWN-REGULATES REELIN EXPRESSION BY METHYLATION OF ITS PROMOTER AND INDUCES ADULT BEHAVIORAL IMPAIRMENTS IN RATS.

Prenatal stress down-regulates Reelin expression by methylation of its promoter and induces adult behavioral impairments in rats.

Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia.The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and

read more